Asymmetic Organocatalytic 1,3-Dipolar Cycloaddition of Azomethine Ylide to Methyl 2-(2-Nitrophenyl)acrylate for the Synthesis of Diastereoisomers of Spirotryprostatin A

被引：105
|
作者：
Chang, Mou-Nuo
Wang, Hao
Gong, Liu-Zhu [1 ]
机构：
[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Peoples R China
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 09期
关键词：
MAMMALIAN-CELL CYCLE; (-)-SPIROTRYPROSTATIN-B; ESTERS;
D O I：
10.1021/ol200652j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The total synthesis of two diastereomers of spirotryprostatin A has been established starting with an asymmetric 1,3-dipolar cycloaddition of methyl 2-(2-nitrophenyl)acrylate with azomethine ylides catalyzed by a Bronsted acid.
引用
收藏
页码：2418 / 2421
页数：4
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