Thalamocortical model for a propofol-induced α-rhythm associated with loss of consciousness

被引：301

作者：

Ching, ShiNung ^{[1
,2
,3
,4
]}

Cimenser, Aylin ^{[1
,2
,5
]}

Purdon, Patrick L. ^{[1
,2
,5
]}

Brown, Emery N. ^{[1
,2
,5
,6
]}

Kopell, Nancy J. ^{[3
,4
]}

机构：

[1] Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA

[2] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA

[3] Boston Univ, Dept Math, Boston, MA 02215 USA

[4] Boston Univ, Ctr BioDynam, Boston, MA 02215 USA

[5] Harvard Univ, Sch Med, Boston, MA 02115 USA

[6] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2010年 / 107卷 / 52期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

general anesthesia; oscillations; global coherence; GABA; LESS-THAN-1 HZ OSCILLATION; INHIBITORY NEURONS; MU RHYTHM; EEG; MECHANISMS; ATTENTION; SYNCHRONIZATION; MODULATION; NETWORKS; FMRI;

D O I：

10.1073/pnas.1017069108

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent data reveal that the general anesthetic propofol gives rise to a frontal alpha-rhythm at dose levels sufficient to induce loss of consciousness. In this work, a computational model is developed that suggests the network mechanisms responsible for such a rhythm. It is shown that propofol can alter the dynamics in thalamocortical loops, leading to persistent and synchronous alpha-activity. The synchrony that forms in the cortex by virtue of the involvement of the thalamus may impede responsiveness to external stimuli, thus providing a correlate for the unconscious state.

引用

页码：22665 / 22670

页数：6

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