Thalamocortical model for a propofol-induced α-rhythm associated with loss of consciousness

被引:301
作者
Ching, ShiNung [1 ,2 ,3 ,4 ]
Cimenser, Aylin [1 ,2 ,5 ]
Purdon, Patrick L. [1 ,2 ,5 ]
Brown, Emery N. [1 ,2 ,5 ,6 ]
Kopell, Nancy J. [3 ,4 ]
机构
[1] Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA
[2] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA
[3] Boston Univ, Dept Math, Boston, MA 02215 USA
[4] Boston Univ, Ctr BioDynam, Boston, MA 02215 USA
[5] Harvard Univ, Sch Med, Boston, MA 02115 USA
[6] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
general anesthesia; oscillations; global coherence; GABA; LESS-THAN-1 HZ OSCILLATION; INHIBITORY NEURONS; MU RHYTHM; EEG; MECHANISMS; ATTENTION; SYNCHRONIZATION; MODULATION; NETWORKS; FMRI;
D O I
10.1073/pnas.1017069108
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Recent data reveal that the general anesthetic propofol gives rise to a frontal alpha-rhythm at dose levels sufficient to induce loss of consciousness. In this work, a computational model is developed that suggests the network mechanisms responsible for such a rhythm. It is shown that propofol can alter the dynamics in thalamocortical loops, leading to persistent and synchronous alpha-activity. The synchrony that forms in the cortex by virtue of the involvement of the thalamus may impede responsiveness to external stimuli, thus providing a correlate for the unconscious state.
引用
收藏
页码:22665 / 22670
页数:6
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