Confocal microscopic analysis reveals sprouting of primary afferent fibres in rat dorsal horn after spinal cord injury

被引：38
|
作者：
Wong, ST [1 ]
Atkinson, BA [1 ]
Weaver, LC [1 ]
机构：
[1] John P Robarts Res Inst, Neurodegenerat Res Grp, London, ON N6A 5K8, Canada
来源：
NEUROSCIENCE LETTERS | 2000年 / 296卷 / 2-3期
关键词：
wheat germ agglutinin; Texas Red (TM); calcitonin gene related peptide; cholera toxin subunit B; confocal microscopy;
D O I：
10.1016/S0304-3940(00)01601-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Following high thoracic spinal cord transection (SCT) in rats, abnormal changes in arterial pressure in response to sensory stimulation (autonomic dysreflexia) are correlated with changes in neural circuitry in the injured spinal cord. Anterograde transport of wheat germ agglutinin conjugated to Texas Red(TM) (WGATR) and confocal microscopy were used to characterize the increased arbourization of A delta and A beta fibre populations in laminae III-V of the dorsal horn. In cord-injured animals, significantly greater areas of WGATR-labeled fibres were found in the deeper laminae of the dorsal horn than in control rats. This increased area likely reflects sprouting of the A delta, A beta, and possibly C fibre populations. The time course of sprouting matches the onset of autonomic dysreflexia, indicating a possible functional correlation between the two phenomena. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：65 / 68
页数：4
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