Molecular cloning and characterization of the polymorphic MHC class II DBB from the tammar wallaby (Macropus eugenii)

被引：19
|
作者：
Browning, TL
Belov, K
Miller, RD
Eldridge, MDB [1 ]
机构：
[1] Macquarie Univ, Dept Biol Sci, Sydney, NSW 2109, Australia
[2] Australian Museum, Evolutionary Biol Unit, Sydney, NSW 2010, Australia
[3] Univ New Mexico, Dept Biol, Albuquerque, NM 87131 USA
[4] Univ New Mexico, Dept Pathol, Albuquerque, NM 87131 USA
来源：
IMMUNOGENETICS | 2004年 / 55卷 / 11期
基金：
美国国家科学基金会; 澳大利亚研究理事会;
关键词：
tammar wallaby; MHC class II; DBB; marsupial; macropod;
D O I：
10.1007/s00251-004-0644-7
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Genes of the major histocompatibility complex (MHC) have been characterized in all extant lineages of mammals. The tammar wallaby (Macropus eugenii) is well established as a model marsupial species; however, no classical MHC sequences have been described from this species. We have isolated two MHC class II beta-chain sequences from a tammar wallaby spleen cDNA library using a tammar MHC class II beta probe. These sequences belong to the marsupial MHC class II DBB gene family. Two additional DBB sequences were amplified from tammar wallaby genomic DNA. All four sequences were obtained from the same individual, indicating that there are at least two DBB loci in the tammar wallaby.
引用
收藏
页码：791 / 795
页数：5
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