Molecular modeling and docking analysis of aspirin with pde7b in the context of neuro-inflammation

被引：3

作者：

Balasundaram, Arthi ^{[1
]}

David, Darling Chellathai ^{[1
]}

机构：

[1] Sri Ramachandra Inst Higher Educ & Res DU, Sri Ramachandra Med Coll & Res Inst, Dept Pharmacol, Chennai 116, Tamil Nadu, India

来源：

BIOINFORMATION | 2020年 / 16卷 / 02期

关键词：

aspirin; PDE7B; cognitive impairments; molecular docking; homology modelling; CLONING;

D O I：

10.6026/97320630016183

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The PDE7B gene encodes 3'5'-cyclic nucleotide phosphodiesterase (PDE) and a known target in cognitive impairments. Therefore, it is of interest to design and development of potential inhibitors with PDE7B with improved binding features. We document that the amino acid residues such as H186, K190, and G113 of PDE7B protein showed crucial interactions with aspirin for further consideration in this context.

引用

页码：183 / 188

页数：6

共 11 条

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