Isodicentric Y chromosomes and secondary microchromosomes

被引：0
|
作者：
Rivera, H
Ayala-Madrigal, LM
Gutiérrez-Angulo, M
Vasquez, AI
Ramos, AL
机构：
[1] Inst Mexicano Seguro Social, Div Genet, Guadalajara, Jalisco, Mexico
[2] Univ Guadalajara, Guadalajara 44430, Jalisco, Mexico
来源：
GENETIC COUNSELING | 2003年 / 14卷 / 02期
关键词：
isodicentric; Y-chromosomes; microchromosomes; functional dicentricity; centromere excision;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Isodicentric Y chromosomes and secondary microchromosomes: We report here on two mosaic patients with both an idic(Yp) and a microchromosome. FISH with the DYZ3 alphoid repeat demonstrated that the isodicentrics effectively exhibited two alphoid clusters whereas the small markers had a Y-centromere. These data, along with 4 previous observations, indicate that such microchromosomes effectively result from functional dicentricity of isodicentric Y-chromosomes and represent the excision of one centromere plus various amounts of adjacent chromatin. Other than a real infrequency of such a concurrence or a very low proportion of the cell line(s) containing the microchromosome, the paucity of observations points to a high rate of underdiagnosis as revealed by two idic(Y) instances in which the microchromosome was detected only in samples assessed by FISH.
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收藏
页码：227 / 231
页数：5
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