Phase 1 open-label, multiple ascending dose trial of AGEN1884, an anti-CTLA-4 monoclonal antibody, in advanced solid malignancies

被引:0
|
作者
Wilky, Breelyn A.
Kumthekar, Priya
Wesolowski, Robert
Hwang, Jimmy J.
Raizer, Jeffrey J.
Gentry, Carleen
Ross, Ainsley
Drouin, Elise
Wilson, Nicholas
Shebanova, Olga
Goldberg, John M.
Buell, Jennifer
Stein, Robert Benjamin
Cuillerot, Jean-Marie
机构
[1] Sylvester Comprehens Canc Ctr, Miami, FL USA
[2] Northwestern Mem Hosp, Chicago, IL 60611 USA
[3] Ohio State Univ, Ctr Comprehens Canc, Arthur G James Canc Hosp, Columbus, OH 43210 USA
[4] Carolinas HealthCare Syst, Levine Canc Inst, Charlotte, NC USA
[5] Agenus Inc, Lexington, MA USA
关键词
D O I
10.1200/JCO.2017.35.15_suppl.3075
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
3075
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Phase I open-label, ascending dose trial of AGEN1884, an anti-CTLA-4 monoclonal antibody, in advanced solid malignancies: Dose selection for combination with PD-1 blockade.
    Wilky, Breelyn A.
    Kumthekar, Priya
    Wesolowski, Robert
    Hwang, Jimmy J.
    Park, Steven I.
    Proscurshim, Igor
    Yuan, Guojun
    Dupont, Christopher D.
    Shebanova, Olga
    Cuillerot, Jean-Marie
    Dow, Edward
    Raizer, Jeffrey J.
    Gentry, Carleen
    Ross, Ainsley
    Drouin, Elise
    Wilson, Nicholas
    Goldberg, John M.
    Buell, Jennifer
    Stein, Robert Benjamin
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
  • [2] Phase I, open-label ascending dose trial of anti-CTLA-4 monoclonal antibody AGEN1884 in advanced solid malignancies, with expansion to patients refractory to recent anti-PD-1/PD-L1 therapy
    Wilky, B. A.
    Kumthekar, P.
    Wesolowski, R.
    Hwang, J. J.
    Park, S. I.
    Yuan, G.
    Dupont, C. D.
    Lim, M.
    Shebanova, O.
    Cuillerot, J-M.
    Dow, E.
    Ortuzar, W.
    Raizer, J. J.
    Drouin, E.
    Wilson, N.
    Gonzalez, A. M.
    Goldberg, J. M.
    Buell, J. S.
    Stein, R. B.
    Youssoufian, H.
    ANNALS OF ONCOLOGY, 2018, 29
  • [3] Phase 1/2 open-label, multiple ascending dose trial of AGEN2034, an anti-PD-1 monoclonal antibody, in advanced solid malignancies: Results of dose escalation.
    Moore, Kathleen N.
    Dresher, Charles
    Liu, Joyce
    O'Malley, David M.
    Wang, Edward Wenge
    Wang, Judy Sing-Zan
    Subbiah, Vivek
    Wilky, Breelyn A.
    Yuan, Guojun
    Dupont, Christopher D.
    Gonzalez, Ana M.
    Savitsky, David
    Coulter, Sara
    Shebanova, Olga
    Dow, Ed
    Proscurshim, Igor
    Buell, Jennifer
    Stein, Robert Benjamin
    Youssoufian, Hagop
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
  • [4] Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody
    Gombos, Randi B.
    Gonzalez, Ana
    Manrique, Mariana
    Chand, Dhan
    Savitsky, David
    Morin, Benjamin
    Breous-Nystrom, Ekaterina
    Dupont, Christopher
    Ward, Rebecca A.
    Mande, Cornelia
    Duckless, Benjamin
    Tango, Hao
    Findeis, Mark A.
    Schuster, Andrea
    Weight, Jeremy D.
    Underwood, Dennis
    Clarke, Christopher
    Ritter, Gerd
    Merghoub, Taha
    Scheer, David
    Wolchok, Jedd D.
    van Dijk, Marc
    Buell, Jennifer S.
    Cuillerot, Jean-Marie
    Stein, Robert
    Drouin, Elise E.
    Wilson, Nicholas S.
    PLOS ONE, 2018, 13 (04):
  • [5] An open-label, multiple ascending dose study of the anti-CTLA-4 antibody ipilimumab in viremic HIV patients
    Colston, Elizabeth
    Grasela, Dennis
    Gardiner, David
    Bucy, R. Pat
    Vakkalagadda, Blisse
    Korman, Alan J.
    Lowy, Israel
    PLOS ONE, 2018, 13 (06):
  • [6] Phase I open-label, multiple ascending dose trial of MSB0010718C, an anti-PD-L1 monoclonal antibody, in advanced solid malignancies.
    Heery, Christopher Ryan
    Coyne, Geraldine Helen O'Sullivan
    Madan, Ravi Amrit
    Schlom, Jeffrey
    von Heydebreck, Anja
    Cuillerot, Jean-Marie
    Sabzevari, Helen
    Gulley, James L.
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
  • [7] Characterization of the anti-CTLA-4 antibody AGEN1884, including toxicology and pharmacology assessments in non-human primates
    Gombos, Randi
    Gonzalez, Ana
    Manrique, Mariana
    Chand, Dhan
    Savitsky, David
    Morin, Benjamin
    Breous-Nystrom, Ekaterina
    Dupont, Christopher
    Ward, Rebecca
    Mundt, Cornelia
    Duckless, Benjamin
    Tang, Hao
    Findeis, Mark
    Schuster, Andrea
    Waight, Jeremy
    Underwood, Dennis
    Clarke, Christopher
    Ritter, Gerd
    Merghoub, Taha
    Schaer, David
    van Dijk, Marc
    Buell, Jennifer
    Cuillerot, Jean-Marie
    Stein, Robert
    Drouin, Elise
    WIlson, Nicholas
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5
  • [8] Phase I/II, open-label, multiple ascending dose trial of AGEN2034, an anti-PD-1 monoclonal antibody, in advanced solid malignancies: Results of dose escalation in advanced cancer and expansion cohorts in subjects with relapsed/refractory cervical cancer
    Drescher, C.
    Moore, K. N.
    Liu, J. F.
    O'Malley, D. M.
    Wang, E. W.
    Wang, J. S-Z.
    Subbiah, V.
    Wilky, B. A.
    Yuan, G.
    Dupont, C. D.
    Gonzalez, A. M.
    Savitsky, D.
    Coulter, S.
    Shebanova, O.
    Dow, E.
    Ortuzar, W.
    Buell, J. S.
    Stein, R. B.
    Youssoufian, H.
    ANNALS OF ONCOLOGY, 2018, 29
  • [9] Toripalimab in combination with HBM4003, an anti-CTLA-4 heavy chain-only antibody, in advanced melanoma and other solid tumors: an open-label phase I trial
    Tang, Bixia
    Chen, Yu
    Jiang, Yu
    Fang, Meiyu
    Gao, Quanli
    Ren, Xiubao
    Yao, Li
    Huang, Gang
    Chen, Jing
    Zhang, Xiaoshi
    Li, Rongqing
    Zhao, Shuai
    Gao, Meijuan
    Luo, Ruixuan
    Qi, Meng
    Li, Feng
    Zheng, Fei
    Lee, Michael
    Tao, Xiaolu
    Duan, Rong
    Guo, Jun
    Chi, Zhihong
    Cui, Chuanliang
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2024, 12 (10)
  • [10] Open-label, phase I, dose escalation/expansion trial of the anti-SIRPa monoclonal antibody BI 770371 in patients with advanced solid tumours, alone or in combination with the anti-PD-1 monoclonal antibody ezabenlimab
    Gutierrez, M.
    Jamal, R.
    Yamamoto, N.
    Doi, T.
    Elgadi, M.
    Ferrada, J. L.
    Wojciekowski, S. M.
    Patel, M. R.
    ANNALS OF ONCOLOGY, 2023, 34 : S485 - S485