Thannilignan glucoside and 2-(β-glucopyranosyl)-3-isoxazolin-5-one derivative, two new compounds isolated from Terminalia bellirica

被引：5
|
作者：
Manome, Teruhisa [1 ]
Hara, Yasumasa [1 ,2 ]
Ahmed, Firoj [3 ]
Sadhu, Samir K. [4 ]
Ishibashi, Masami [1 ,2 ]
机构：
[1] Chiba Univ, Grad Sch Pharmaceut Sci, Chuo Ku, 1-8-1 Inohana, Chiba 2608675, Japan
[2] Chiba Univ, Plant Mol Sci Ctr, Chuo Ku, 1-8-1 Inohana, Chiba 2608675, Japan
[3] Univ Dhaka, Dept Pharmaceut Chem, Dhaka 1000, Bangladesh
[4] Khulna Univ, Pharm Discipline, Khulna 9208, Bangladesh
来源：
JOURNAL OF NATURAL MEDICINES | 2022年 / 76卷 / 02期
基金：
日本学术振兴会;
关键词：
Terminalia bellirica; TRAIL resistance; AGS cytotoxicity; Bangladeshi plant; TRAIL; CONSTITUENTS;
D O I：
10.1007/s11418-021-01593-z
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new compounds, thannilignan 9-O-beta-glucoside (1) and 2-(beta-glucopyranosyl)-3-isoxazolin-5-one derivative (2), and seven known compounds were isolated from the methanol extract of Terminalia bellirica leaves, collected in Bangladesh. The structures of the compounds were elucidated using spectroscopic analysis. Among these isolated compounds, corilagin (3) was cytotoxic against human gastric adenocarcinoma cell line AGS at an IC50 of 20.8 mu M, and beta-d-glucopyranose 1,3,6-trigallate (4) exhibited the ability to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance.
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页码：482 / 489
页数：8
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