Comparative Efficacies of Tedizolid Phosphate, Linezolid, and Vancomycin in a Murine Model of Subcutaneous Catheter-Related Biofilm Infection Due to Methicillin-Susceptible and -Resistant Staphylococcus aureus

被引：19
|
作者：
Bayer, Arnold S. [1 ,2 ]
Abdelhady, Wessam [1 ]
Li, Liang [1 ]
Gonzales, Rachelle [1 ]
Xiong, Yan Q. [1 ,2 ]
机构：
[1] Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Torrance, CA 90509 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2016年 / 60卷 / 08期
关键词：
SKIN-STRUCTURE INFECTIONS; EXPERIMENTAL ENDOCARDITIS; MOUSE MODEL; OXAZOLIDINONE; ANTIBIOTICS; DAPTOMYCIN; TELAVANCIN; PNEUMONIA; MICE; RAT;
D O I：
10.1128/AAC.00880-16
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Tedizolid, a novel oxazolidinone, exhibits bacteriostatic activity through inhibition of protein synthesis. The efficacies of tedizolid, linezolid, and vancomycin were compared in a murine catheter-related biofilm infection caused by methicillin-susceptible and -resistant Staphylococcus aureus (MSSA and MRSA, respectively) strains engineered for bioluminescence. We observed significantly improved efficacy in terms of decreased S. aureus densities and bioluminescent signals in the tedizolid-treated group versus the linezolid-and vancomycin-treated groups in the model of infection caused by the MSSA and MRSA strains.
引用
收藏
页码：5092 / 5096
页数：5
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