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Yonsei Univ, Coll Med, Div Rheumatol,Inst Immunol & Immunol Dis, Dept Internal Med,Brain Korea Project Med Sci 21, Seoul 120752, South Korea Yonsei Univ, Coll Med, Div Rheumatol,Inst Immunol & Immunol Dis, Dept Internal Med,Brain Korea Project Med Sci 21, Seoul 120752, South Korea