Background: Patient safety culture is an essential factor in the decreasing of medical errors and development of the institutions. This study was conducted to determine to what extent the selected variables, including age, weekly working hours, years of experience, burnout, turnover intention, workload, and job satisfaction, predict perceived patient safety culture among emergency nurses in Jordanian hospitals. Methods: A cross-sectional design with convenience sampling approach was used. A total of 157 emergency nurses from governmental and public hospitals were participated in the study and completed the study's survey: Hospital Survey on Patient Safety Culture (PSC), Copenhagen Burnout Inventory-Student Survey (CBI-SS), NASA Task Load Index (NASA-TLX), Nursing Workplace Satisfaction Questionnaire (NWSQ) and turnover intention scale (TIS). Results: The results showed that there was a negative relationship found between nurses' age and PSC perception (r = -.166, P = .039), personal burnout and PSC (r = -.160, P = .048), and there was also a negative relationship between turnover intentions and perceived PSC (r = -.334, P = .000). The results from the regression model indicated that turnover intentions, reporting patient safety events, and the number of events reported predicted PSC. The results showed that R-2 = .29, adjusted R-2 = .287, F(6,141) = 9.45, P < 0.01. Conclusion: Our results suggests that nurses' managers may pay attention to decreasing burnout and analyze turnover intention among nurses in order to improve the culture of patient safety. (C) 2021 FECA. Published by Elsevier Espan tilde a, S.L.U. All rights reserved.