Characteristics of Diffusion in the Corticospinal Tract of Patients with Early Stage of Schizophrenia: Diffusion Tensor Magnetic Resonance Imaging

被引：6

作者：

Ublinskii, M. V. ^{[1
,2
]}

Semenova, N. A. ^{[1
,2
]}

Lukovkina, O. V. ^{[1
]}

Sidorin, S. V. ^{[1
,2
]}

Lebedeva, I. S. ^{[3
]}

Kaleda, V. G. ^{[3
]}

Barkhatova, A. N. ^{[3
]}

Akhadov, T. A. ^{[1
]}

机构：

[1] Russian Acad Sci, Res Inst Urgent Children Surg & Traumatol, Moscow, Russia

[2] Russian Acad Sci, NM Emanuel Inst Biochem Phys, Moscow, Russia

[3] Russian Acad Med Sci, Mental Hlth Res Ctr, Moscow 109801, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2015年 / 159卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

diffusion tensor magnetic resonance imaging; schizophrenia; corticospinal tract; CORPUS-CALLOSUM; ADOLESCENCE; CHILDHOOD;

D O I：

10.1007/s10517-015-2881-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Specific features of diffusion in the cerebral corticospinal tract of patients with early stages of schizophrenia were studied using methods of diffusion tensor magnetic-resonance imaging and magnetic resonance spectroscopy. A decrease in the coefficient of fractional anisotropy in the posterior limb of the internal capsule and an increase in diffusion coefficient in the radiate crown and motor cortex were observed. The results reflect different mechanisms of changes in water diffusion in various areas of the corticospinal tract: changes in nerve fiber microstructure in the internal capsule of the left hemisphere and a decrease in their density in the motor cortex and radiate crown.

引用

页码：29 / 31

页数：3

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