The enhanced permeability and retention effect based nanomedicine at the site of injury

被引：53

作者：

Liu, Yingjun ^{[1
]}

Sun, Dongdong ^{[2
]}

Fan, Qin ^{[1
]}

Ma, Qingle ^{[1
]}

Dong, Ziliang ^{[1
]}

Tao, Weiwei ^{[2
]}

Tao, Huiquan ^{[1
]}

Liu, Zhuang ^{[1
]}

Wang, Chao ^{[1
]}

机构：

[1] Soochow Univ, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Peoples R China

[2] Nanjing Univ Chinese Med, Collaborat Innovat Ctr Jiangsu Prov Canc Prevent, Sch Integrated Chinese & Western Med, Nanjing 210023, Peoples R China

来源：

NANO RESEARCH | 2020年 / 13卷 / 02期

基金：

中国国家自然科学基金;

关键词：

enhanced permeability retention (EPR) effect; injured tissue; polymeric nanoparticles; histamine; immune response; PROLONGED VASCULAR LEAKAGE; INFLAMMATION; NANOPARTICLES; HISTAMINE; MECHANISM; DELIVERY; BARRIER;

D O I：

10.1007/s12274-020-2655-6

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The enhanced permeability retention (EPR) effect based nanomedicine has been widely used for tumor targeting during the past decades. Here we unexpectedly observed the similar "EPR effect" at the site of injury. We found that the temporary dilated and leaky blood vessels caused by the potent vasodilator histamine in response to injury allowed the injected nanoparticles to pass through the vasculature and reached the injured tissue. Our finding shows the potential underline mechanism of "EPR effect" at the injured site. By loading with antibiotics, we further demonstrated a new strategy for prevention of infection at the site of injury.

引用

页码：564 / 569

页数：6

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