Effect of (-)-stepholidine on serum prolactin level of female rats

被引：0
|
作者：
Zou, LL [1 ]
Chen, Y [1 ]
Song, YY [1 ]
Jin, GZ [1 ]
机构：
[1] CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA
来源：
ACTA PHARMACOLOGICA SINICA | 1996年 / 17卷 / 04期
关键词：
(-)-stepholidine; prolactin; radioimmunoassay; dopamine antagonists; pergolide;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
AIM: To study the effect of (-)-stepholidine (SPD) on serum prolactin (PRL) level and elucidate its pharmacological action on,dopamine D-2 receptors. METHOD: After ip administration of dopamine receptor agonist, antagonist, or SPD, the serum PRL levels were determined by radioimmunoassay. RESULTS: SPD (24 mg . kg(-1), ip) caused a rapid rise in serum PRL level, lasting more than 1 h. SPD 0.2-40 mg . kg(-1) raised serum PRL level in a dose-dependent manner with ED(50) of 3.7 mg . kg(-1) (95 % confidence limits, 2.6-4.3 mg . kg(-1)) and PRL maximal level of 448 +/-64 mu g . L(-1). Pergolide 2 mg . kg(-1) ip caused a decrease (P < 0.01 vs saline) of PRL level, which was partially attenuated by SPD of 5 mg . kg(-1) and completely abolished by 10 mg . kg(-1). CONCLUSION: SPD is a dopamine D-2 receptor antagonist.
引用
收藏
页码：311 / 314
页数：4
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