An entry to vinylcyclopropane through palladium-catalyzed intramolecular cyclopropanation of alkenes with unstabilized allylic tosylhydrazones

被引：29
|
作者：
Yang, Yang [1 ]
Li, Jinpeng [1 ]
Du, Biao [1 ]
Yuan, Changchun [1 ]
Liu, Bo [1 ,2 ]
Qin, Song [1 ]
机构：
[1] Sichuan Univ, Coll Chem, Minist Educ, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China
[2] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 28期
基金：
中国国家自然科学基金;
关键词：
DIAZO-COMPOUNDS; ORGANIC-SYNTHESIS; H INSERTION; REARRANGEMENT; DERIVATIVES; INTERMEDIATE; ANNULATION; REAGENTS; ETHERS; BONDS;
D O I：
10.1039/c5cc00235d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A diastereoselective Pd-catalyzed intramolecular cyclopropanation of alkenes with unstabilized allylic tosylhydrazones was developed. This methodology provides an efficient entry toward synthesis of the bicyclo[3.1.0] hexane system with an exo-double bond, and sets the basis for future elaboration of more complex polycyclic motifs.
引用
收藏
页码：6179 / 6182
页数：4
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