Receipt of Older RBCs Does Not Predispose D-Negative Recipients to Anti-D Alloimmunization

被引：16
|
作者：
Yazer, Mark H. [1 ]
Triulzi, Darrell J.
机构：
[1] Univ Pittsburgh, Inst Transfus Med, Pittsburgh, PA 15213 USA
来源：
AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2010年 / 134卷 / 03期
关键词：
RhD; Alloimmunization; RBC; Storage lesion; Inflammation; PRESTORAGE; CELLS; STORAGE; TRANSFUSION; SUPERNATANT; POPULATION; GENERATION; ANTIBODIES; FILTRATION; FREQUENCY;
D O I：
10.1309/AJCP2J8SVWOXRLRB
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The effect of the age of RBCs on anti-RBC alloimmunization has not been investigated in previous studies the RBC storage lesion. D-negative recipients of at least 1 D-positive RBC unit were identified. Responders produced an anti-D, while nonresponders had not made anti-D when the database was searched. The 2 groups were matched for age, sex, length of serologic follow-up. and hospital location. There were 29 responders and 58 nonresponders. The median number of all RBCs transfused to the responders was 6, vs 10 for the nonresponders (P < .01): the median age of the RBCs was 15 vs 14 days, respectively (P = .70). Responders received a median of 3 D-positive RBC units vs 4 D-positive RBCs for nonresponders (P 02); median ages of the D-positive RBCs were 16 vs 14 days, respectively (P = .21). There was no association between the age of transfused RBCs and the likelihood of anti-D alloimmunization.
引用
收藏
页码：443 / 447
页数：5
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