Inhibitory Activity of α-Amylase and α-Glucosidase by Plant Extracts from the Brazilian Cerrado

被引：66
|
作者：
de Souza, Paula Monteiro [1 ,2 ]
de Sales, Paloma Michelle [1 ]
Simeoni, Luiz Alberto [1 ]
Silva, Elton Clementino
Silveira, Damaris [1 ]
Magalhaes, Perola de Oliveira [1 ]
机构：
[1] Univ Brasilia, Dept Pharmaceut Sci, Sch Hlth Sci, BR-70919970 Brasilia, DF, Brazil
[2] Univ Brasilia, Dept Farm, Fac Ciencias Saude, BR-70919970 Brasilia, DF, Brazil
来源：
PLANTA MEDICA | 2012年 / 78卷 / 04期
关键词：
enzyme inhibition; alpha-amylase; alpha-glucosidase; cerrado; Brazilian savannah; diabetes; ORAL ANTIHYPERGLYCEMIC THERAPY; IN-VITRO; QUALEA-GRANDIFLORA; EUGENIA; DERIVATIZATION; HYPERGLYCEMIA; HERB; ACID;
D O I：
10.1055/s-0031-1280404
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Diabetes mellitus is the most common disease in the world. One therapeutic approach for treating diabetes is inhibition of alpha-amylase and alpha-glucosidase activities to reduce postprandial blood glucose levels. In vitro tests showed that several plant extracts from Brazilian cerrado species can inhibit the activity of alpha-amylase and alpha-glucosidase. The extracts of Eugenia dysenterica, Stryphnodendron adstringens, Pouteria caimito, Pouteria ramiflora, and Pouteria torta showed strong alpha-amylase and alpha-glucosidase inhibitory activity. Eugenia dysenterica, P. caimito, P. ramiflora, and P. torta aqueous extracts exerted the highest activity against alpha-amylase (IC50 values of 14.93, 13.6, 7.08, and 5.67 mu g/mL, respectively) and alpha-glucosidase (IC50 values of 0.46, 2.58, 0.35, and 0.22 mu g/mL, respectively). Stryphnodendron adstringens ethanol extract also exhibited inhibitory activity against both enzymes (IC50 1.86 mu g/mL against alpha-amylase and 0.61 mu g/mL against alpha-glucosidase). The results suggest that the activity of these cerrado plants on alpha-amylase and alpha-glucosidase represents a potential tool for development of new strategies for treatment of diabetes.
引用
收藏
页码：393 / 399
页数：7
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