Acinetobacter baumannii:: Emergence of a successful pathogen

被引:2558
|
作者
Peleg, Anton Y. [1 ,2 ]
Seifert, Harald [3 ]
Paterson, David L. [4 ,5 ]
机构
[1] Beth Israel Deaconess Med Ctr, Div Infect Dis, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Univ Cologne, Inst Med Microbiol Immunol & Hyg, D-50935 Cologne, Germany
[4] Univ Queensland, Royal Brisbane & Womens Hosp, Brisbane, Qld, Australia
[5] Univ Pittsburgh, Sch Med, Div Infect Dis, Pittsburgh, PA USA
基金
美国国家卫生研究院;
关键词
D O I
10.1128/CMR.00058-07
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Acinetobacter baumannii has emerged as a highly troublesome pathogen for many institutions globally. As a consequence of its immense ability to acquire or upregulate antibiotic drug resistance determinants, it has justifiably been propelled to the forefront of scientific attention. Apart from its predilection for the seriously ill within intensive care units, A. baumannii has more recently caused a range of infectious syndromes in military personnel injured in the Iraq and Afghanistan conflicts. This review details the significant advances that have been made in our understanding of this remarkable organism over the last 10 years, including current taxonomy and species identification, issues with susceptibility testing, mechanisms of antibiotic resistance, global epidemiology, clinical impact of infection, host-pathogen interactions, and infection control and therapeutic considerations. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
引用
收藏
页码:538 / 582
页数:45
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