Cardiovascular determinants and prognostic significance of CC Chemokine Ligand-18 (CCL18/PARC) in patients with stable coronary artery disease

被引：13
作者：
De Sutter, J. [1 ,2 ]
Struyf, S. [3 ]
de Veire, N. R. Van [1 ]
Philippe, J. [4 ]
De Buyzere, M. [2 ]
Van Damme, J. [3 ]
机构：
[1] AZ Maria Middelares Gent, Dept Cardiol, B-9000 Ghent, Belgium
[2] Ghent Univ Hosp, Ctr Heart, Ghent, Belgium
[3] Univ Leuven, Rega Inst, Lab Mol Immunol, Louvain, Belgium
[4] Univ Ghent, Dept Clin Chem Microbiol & Immunol, Ghent, Belgium
来源：
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2010年 / 49卷 / 05期
关键词：
Human stable coronary artery disease; Chemokines; Cardiac function; Exercise capacity; Interleukin-6; Prognosis; ACTIVATION-REGULATED CHEMOKINE; GATED SPECT; PROTEIN-1; MONOCYTES; PARC;
D O I：
10.1016/j.yjmcc.2010.07.013
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Chemokines are important mediators of angiogenesis, hematopoiesis and leucocyte trafficking. CC Chemokine Ligand-18 (CCL18)/ pulmonary and activation-regulated chemokine (PARC) is a circulating chemokine that plays a role in injury healing, physiological homing of mononuclear blood cells and inflammatory responses. CCL18/PARC is also expressed in atherosclerotic plaques. We prospectively evaluated CCL18/PARC levels and their cardiovascular and biological determinants in a large cohort of 285 patients with stable coronary heart disease who were subsequently followed for 3 years for hard cardiac events. It was found that CCL18/PARC levels were associated with decreased cardiac function, decreased exercise capacity and increased inflammatory parameters including interleukin-6 (IL-6) and hs-CRP. More importantly high CCL18/PARC levels were an independent predictor of future cardiovascular events. Therefore, CCL18/PARC is a potential diagnostic and prognostic parameter in patients with stable coronary artery disease. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：894 / 896
页数：3
相关论文
共 18 条
[1]   Pulmonary and activation-regulated chemokine stimulates collagen production in lung fibroblasts [J].
Atamas, SP ;
Luzina, IG ;
Choi, J ;
Tsymbalyuk, N ;
Carbonetti, NH ;
Singh, IS ;
Trojanowska, M ;
Jimenez, SA ;
White, B .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2003, 29 (06) :743-749
[2]   Chemokines provide the sustained inflammatory bridge between innate and acquired immunity [J].
Coelho, AL ;
Hogaboam, CM ;
Kunkel, SL .
CYTOKINE & GROWTH FACTOR REVIEWS, 2005, 16 (06) :553-560
[3]   Association between plasma levels of monocyte chemoattractant protein-1 and long-term clinical outcomes in patients with acute coronary syndromes [J].
de Lemos, JA ;
Morrow, DA ;
Sabatine, MS ;
Murphy, SA ;
Gibson, CM ;
Antman, EM ;
McCabe, CH ;
Cannon, CP ;
Braunwald, E .
CIRCULATION, 2003, 107 (05) :690-695
[4]   Incremental prognostic value of combined perfusion and function assessment during myocardial gated SPECT in patients aged 75 years or older [J].
De Winter, O ;
Velghe, A ;
Van de Veire, N ;
De Bondt, P ;
De Buyzere, M ;
Van de Wiele, C ;
De Backer, G ;
Gillebert, TC ;
Dierckx, RA ;
De Sutter, J .
JOURNAL OF NUCLEAR CARDIOLOGY, 2005, 12 (06) :662-670
[5]   Day-to-day variability of global left ventricular functional and perfusional measurements by quantitative gated SPECT using Tc-99m tetrofosmin in patients with heart failure due to coronary artery disease [J].
De Winter, O ;
De Bondt, P ;
Van De Wiele, C ;
De Backer, G ;
Dierckx, RA ;
De Sutter, J .
JOURNAL OF NUCLEAR CARDIOLOGY, 2004, 11 (01) :47-52
[6]  
Hieshima K, 1997, J IMMUNOL, V159, P1140
[7]   CC chemokine ligand-5 (CCL5/RANTES) and CC chemokine ligand-18 (CCL18/PARC) are specific markers of refractory unstable angina pectoris and are transiently raised during severe ischemic symptoms [J].
Kraaijeveld, A. O. ;
de Jager, S. C. A. ;
de Jager, W. J. ;
Prakken, B. J. ;
McColl, S. R. ;
Haspels, I. ;
Putter, H. ;
van Berkel, T. J. C. ;
Nagelkerken, L. ;
Jukema, J. W. ;
Biessen, E. A. L. .
CIRCULATION, 2007, 116 (17) :1931-1941
[8]   Chemokines and thrombogenicity [J].
Lambert, Michele P. ;
Sachais, Bruce S. ;
Kowalska, M. Anna .
THROMBOSIS AND HAEMOSTASIS, 2007, 97 (05) :722-729
[9]   Inflammation in Atherosclerosis From Pathophysiology to Practice [J].
Libby, Peter ;
Ridker, Paul M. ;
Hansson, Goran K. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 54 (23) :2129-2138
[10]   The chemokine system: redundancy for robust outputs [J].
Mantovani, A .
IMMUNOLOGY TODAY, 1999, 20 (06) :254-257
12