Canoe functions at the CNS midline glia in a complex with Shotgun and Wrapper-Nrx-IV during neuron-glia interactions

被引:11
|
作者
Slovakova, Jana [1 ]
Carmena, Ana [1 ]
机构
[1] CSIC UMH, Inst Neurociencias Alicante, Alicante 03550, Spain
来源
DEVELOPMENT | 2011年 / 138卷 / 08期
关键词
Neuron-glia interactions; Canoe/AF-6; Drosophila; CNS; Wrapper; DE-cadherin; Nrx-IV; Midline; CENTRAL-NERVOUS-SYSTEM; DROSOPHILA CNS; ADHERENS JUNCTIONS; SEPTATE JUNCTION; GENE-EXPRESSION; ACTIN CYTOSKELETON; COMMISSURAL AXONS; GROWTH CONES; NEUREXIN IV; PROTEIN;
D O I
10.1242/dev.056192
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Vertebrates and insects alike use glial cells as intermediate targets to guide growing axons. Similar to vertebrate oligodendrocytes, Drosophila midline glia ensheath and separate axonal commissures. Neuron-glia interactions are crucial during these events, although the proteins involved remain largely unknown. Here, we show that Canoe (Cno), the Drosophila ortholog of AF-6, and the DE-cadherin Shotgun (Shg) are highly restricted to the interface between midline glia and commissural axons. cno mutant analysis, genetic interactions and co-immunoprecipitation assays unveil Cno function as a novel regulator of neuron-glia interactions, forming a complex with Shg, Wrapper and Neurexin IV, the homolog of vertebrate Caspr/paranodin. Our results also support additional functions of Cno, independent of adherens junctions, as a regulator of adhesion and signaling events in non-epithelial tissues.
引用
收藏
页码:1563 / 1571
页数:9
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