APPLICATIONS OF NEXT-GENERATION SEQUENCING Reconstructing ancient genomes and epigenomes

被引：137
|
作者：
Orlando, Ludovic [1 ,2 ]
Gilbert, M. Thomas P. [1 ,3 ]
Willerslev, Eske [1 ]
机构：
[1] Univ Copenhagen, Nat Hist Museum Denmark, Ctr GeoGenet, DK-1350 Copenhagen C, Denmark
[2] Univ Toulouse, Univ Paul Sabatier, Lab AMIS, CNRS UMR 5288, F-31000 Toulouse, France
[3] Curtin Univ, Dept Environm & Agr, Trace & Environm DNA Lab, Perth, WA 6102, Australia
来源：
NATURE REVIEWS GENETICS | 2015年 / 16卷 / 07期
基金：
新加坡国家研究基金会;
关键词：
DNA-SEQUENCES; NEANDERTHAL GENOME; MISCODING LESIONS; YERSINIA-PESTIS; READ ALIGNMENT; EVOLUTION; PATTERNS; ANCESTRY; INSIGHTS; HISTORY;
D O I：
10.1038/nrg3935
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Research involving ancient DNA (aDNA) has experienced a true technological revolution in recent years through advances in the recovery of aDNA and, particularly, through applications of high-throughput sequencing. Formerly restricted to the analysis of only limited amounts of genetic information, aDNA studies have now progressed to whole-genome sequencing for an increasing number of ancient individuals and extinct species, as well as to epigenomic characterization. Such advances have enabled the sequencing of specimens of up to 1 million years old, which, owing to their extensive DNA damage and contamination, were previously not amenable to genetic analyses. In this Review, we discuss these varied technical challenges and solutions for sequencing ancient genomes and epigenomes.
引用
收藏
页码：395 / 408
页数：14
相关论文
共 50 条
  • [1] Reconstructing ancient genomes and epigenomes
    Ludovic Orlando
    M. Thomas P. Gilbert
    Eske Willerslev
    Nature Reviews Genetics, 2015, 16 : 395 - 408
  • [2] Next-generation sequencing: applications beyond genomes
    Marguerat, Samuel
    Wilhelm, Brian T.
    Baehler, Juerg
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2008, 36 : 1091 - 1096
  • [3] APPLICATIONS OF NEXT-GENERATION SEQUENCING Sequencing technologies - the next generation
    Metzker, Michael L.
    NATURE REVIEWS GENETICS, 2010, 11 (01) : 31 - 46
  • [4] Ligation Bias in Illumina Next-Generation DNA Libraries: Implications for Sequencing Ancient Genomes
    Seguin-Orlando, Andaine
    Schubert, Mikkel
    Clary, Joel
    Stagegaard, Julia
    Alberdi, Maria T.
    Luis Prado, Jose
    Prieto, Alfredo
    Willerslev, Eske
    Orlando, Ludovic
    PLOS ONE, 2013, 8 (10):
  • [5] Next-generation sequencing and the era of personal Y genomes
    Ayub, Qasim
    Jostins, Luke
    Xue, Yali
    Turner, Daniel
    Tyler-Smith, Chris
    GENOME BIOLOGY, 2010, 11
  • [6] Accessing complex crop genomes with next-generation sequencing
    Edwards, David
    Batley, Jacqueline
    Snowdon, Rod J.
    THEORETICAL AND APPLIED GENETICS, 2013, 126 (01) : 1 - 11
  • [7] Next-generation sequencing profiling of mitochondrial genomes in gout
    Tseng, Chia-Chun
    Chen, Chung-Jen
    Yen, Jeng-Hsien
    Huang, Hsi-Yuan
    Chang, Jan-Gowth
    Chang, Shun-Jen
    Liao, Wei-Ting
    ARTHRITIS RESEARCH & THERAPY, 2018, 20
  • [8] Accessing complex crop genomes with next-generation sequencing
    David Edwards
    Jacqueline Batley
    Rod J. Snowdon
    Theoretical and Applied Genetics, 2013, 126 : 1 - 11
  • [9] Next-generation sequencing of cancer genomes: lessons learned
    Corrigan, Amber E.
    Taylor, Robert
    Rallis, Kathrine S.
    FUTURE ONCOLOGY, 2021, 17 (31) : 4041 - 4044
  • [10] Next-generation sequencing of cancer genomes: back to the future
    Walter, Matthew J.
    Graubert, Timothy A.
    Dipersio, John F.
    Mardis, Elaine R.
    Wilson, Richard K.
    Ley, Timothy J.
    PERSONALIZED MEDICINE, 2009, 6 (06) : 653 - 662
12345