Samanea tubulosa Benth. (Fabaceae): Antinociceptive effect on acute pain in mice: KATP+ channel and opioid activity

被引：0

作者：

Alixandre, Tamnata F. ^{[1
]}

Sousa, Renato P. ^{[3
]}

Gomes, Bruno S. ^{[2
]}

Silva, Aretha H. S. ^{[4
]}

Sousa Neto, Benedito P. ^{[2
]}

Sousa, Elcilene A. ^{[3
]}

Lima, Marluce P. D. ^{[1
]}

Lopes, Everton M. ^{[2
]}

Piauilino, Celyane A. ^{[2
]}

Nascimento, Rejane T. ^{[1
]}

Reis Filho, Antonio C. ^{[2
]}

Almeida, Fernanda R. C. ^{[2
]}

Oliveira, Francisco A. ^{[2
]}

Chaves, Mariana H. ^{[3
]}

Costa, Luciana M. ^{[1
]}

Moraes Alves, Michel M. ^{[4
]}

Costa, Amilton P. R. ^{[4
]}

机构：

[1] Univ Fed Piaui UFPI, Rede Nordeste Biotecnol RENORBIO, Bloco Fisiol,Ave Univ S-N, BR-64049550 Teresina, PI, Brazil

[2] Univ Fed Piaui UFPI, Nucleo Pesquisa Plantas Medicinais NPPM, Ave Univ S-N, BR-64049550 Teresina, PI, Brazil

[3] Univ Fed Piaui UFPI, Dept Quim, Ave Univ S-N,Bloco Quim, BR-64049550 Teresina, PI, Brazil

[4] Univ Fed Piaui UFPI CCA, Dept Morfosiol Vet, Rua Dirce Oliveira S-N, BR-64049550 Teresina, PI, Brazil

来源：

ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS | 2022年 / 94卷 / 02期

关键词：

Analgesic; medicinal plants; natural products; morphine; CENTRAL MECHANISMS; FORMALIN TEST; EXTRACT; MODULATION; ACTIVATION; RECEPTORS;

D O I：

10.1590/0001-3765202120210715

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Samanea tubulosa Benth. it has been widely used in traditional medicine to treat inflammatory processes. The present study aimed to investigate the antinociceptive effect and mechanism of action of the fractions obtained from the Samanea tubulosa pods in mice. The antinociceptive activity was evaluated in formalin, capsaicin and glutamate tests and the. The possible mechanisms of action involved in the antinociceptive effect of the hexane and ethyl acetate fraction in the opioid system, also the the K-ATP(+) channels and the L-arigine pathways of nitric oxide were evaluated. The chemical characterization analysis revealed in the hexane fraction the presence of triterpenes such as lupenone and lupeol. In the glutamate test, the hexane and ethyl acetate fractions showed antinociceptive activity at the dose of 12.5 and 25 mg kg(-1). The antinociception produced by the hexane and ethyl acetate fractions was significantly reversed by naloxone, indicating that the fractions act through the opioid pathway. Antinociceptive response of the ethyl acetate fraction was blocked by glibenclamide, indicating that this fraction acts via the K-ATP(+) channels activation. It is concluded that the fractions under study exert antinociceptive activity possibly related to the opioid route and through K-ATP(+) channels activation.

引用

页数：16

共 3 条

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[3] Synergistic antinociceptive effect of a calcium channel blocker and a TRPV1 blocker in an acute pain model in mice
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