Composite coatings of Mg-MOF74 and Sr-substituted hydroxyapatite on titanium substrates for local antibacterial, anti-osteosarcoma and pro-osteogenesis applications

被引：26

作者：

Zhang, Yangyang ^{[1
]}

Shen, Xinkun ^{[1
,2
]}

Ma, Pingping ^{[1
]}

Peng, Zhihong ^{[3
]}

Cai, Kaiyong ^{[1
]}

机构：

[1] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China

[2] Chongqing Univ, Sch Life Sci, Chongqing 400044, Peoples R China

[3] Third Mil Med Univ, Southwest Hosp, Dept Gastroenterol, Chongqing 400038, Peoples R China

来源：

MATERIALS LETTERS | 2019年 / 241卷

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Biomaterials; Mg-MOF74; Nanocomposites; Surfaces; Antibacterial; Anti-osteosarcoma; SERIES;

D O I：

10.1016/j.matlet.2019.01.033

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

It has been noticed that residual osteosarcoma cells or infective bacteria would greatly hinder the osseointegration between implants and natural bone at the early stage of implant surgeries. Thus, in this work, composite coatings of magnesium-mediated metal-organic frameworks (Mg-MOF74) and strontium-substituted hydroxyapatite (Sr-HA) were constructed on titanium surfaces for improving the local injury treatment even with complications (osteosarcoma or bacterial infection). It was proved that the superficial Mg-MOF74 could rapidly degrade (especially under bacteria- or osteosarcoma-induced acid microenvironment) and effectively kill surrounding Staphylococcus aureus, Escherichia coli and Saos-2 cells, and then the exposed Sr-HA coating had great potential to promote the proliferation and osteogenic differentiation of osteoblasts. (C) 2019 Elsevier B.V. All rights reserved.

引用

页码：18 / 22

页数：5