Neuropilin-1 (NRP-1), a Novel Molecular Target of Glioma

被引：4

作者：

Chen, Lukui ^{[1
]}

Shi, Yan ^{[3
]}

Qiu, Rong ^{[2
]}

机构：

[1] Southeast Univ, Sch Med, Zhongda Hosp, Nanjing 210009, Peoples R China

[2] Southeast Univ, Zhongda Hosp, Dept Neurosurg, Nanjing 210009, Peoples R China

[3] Nanjing Med Univ, Affiliated Nanjing Hosp, Dept Neurosurg, Nanjing 210009, Peoples R China

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2016年 / 16卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Neuropilin-1; Glioma; ENDOTHELIAL-GROWTH-FACTOR; MESENCHYMAL STEM-CELLS; SINGLE-BASE EXTENSION; SMOOTH-MUSCLE-CELLS; GASTRIC-CANCER RISK; MAGNETIC NANOPARTICLES; DNA HYBRIDIZATION; NORTHERN JIANGSU; DETECTION SYSTEM; GOLD NANORODS;

D O I：

10.1166/jnn.2016.11376

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This paper reviews the recent studies of Neuropilin-1 (NRP-1) as a novel molecular target of glioma. In this review, we introduce briefly the properties of the NRP-1. And then we focused on the role of NRP-1 in gliomas, including relationships of NRP-1 expression and glioma prognosis, NRP-1 signaling and p130Cas tyrosine phosphorylation in gliomas, NRP-1 and LD22-4, Sema3A-NRP-1 signaling in gliomas, NRP-1 in the HGF/SF autocrine pathway, NRP-1 and glioma stem-like cells. Finally, it is concluded that NRP-1 could potentially act as a novel therapeutical target of glioma.

引用

页码：6657 / 6666

页数：10

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