Copper-Catalyzed Radical Methylation/C-H Amination/Oxidation Cascade for the Synthesis of Quinazolinones

被引：78
|
作者：
Bao, Yajie
Yan, Yizhe
Xu, Kun
Su, Jihu
Zha, Zhenggen
Wang, Zhiyong [1 ]
机构：
[1] Univ Sci & Technol China, CAS Key Lab Soft Matter Chem, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 09期
关键词：
MEDIATED INTRAMOLECULAR AMINATION; N BOND FORMATION; INTERMOLECULAR AMIDATION; OXIDATIVE AMINATION; C(SP(3))-H BONDS; METHYL ESTERIFICATION; EFFICIENT SYNTHESIS; C-C; ACTIVATION; IODINE;
D O I：
10.1021/acs.joc.5b00191
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A copper-catalyzed radical methylation/sp(3) C-H amination/oxidation reaction for the facile synthesis of quinazolinone was developed. In this cascade reaction, dicumyl peroxide acts not only as a useful oxidant but also as an efficient methyl source. Notably, a methyl radical, generated. from peroxide, was confirmed by electron paramagnetic resonance for the first time.
引用
收藏
页码：4736 / 4742
页数：7
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