The incidence of lymphoid and myeloid malignancies among hospitalized Crohn's disease patients

被引:44
|
作者
Arseneau, KO
Stukenborg, GJ
Connors, AF
Cominelli, F
机构
[1] Univ Virginia, Hlth Syst, Digest Hlth Ctr, Charlottesville, VA USA
[2] Univ Virginia, Hlth Syst, Dept Hlth Evaluat Sci, Charlottesville, VA USA
关键词
Crohn's disease; lymphoma; leukemia; myeloma; incidence; administrative data;
D O I
10.1097/00054725-200105000-00005
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
An association may exist between Crohn's disease (CD) and lymphoid/myeloid malignancies. We aimed to evaluate the 2-year cumulative incidence rate of lymphoid/myeloid malignancy among hospitalized CD patients. This is a retrospective cohort study using hospital discharge data from California and Virginia. Cohorts were defined by the presence or absence of a CD diagnosis in all patients discharged during a single calendar year (Year-2). The presence or absence of lymphoid/myeloid malignancy was determined for all hospitalizations during a l-year period (Year-l to Year-4) for each member of both cohorts. To obtain a 2-year cumulative incidence rate, patients with lymphoid/myeloid malignancy prior to or at the time of their first admission in Year-2 were excluded. Patients were followed for 8 quarters after this admission for the incidence of lymphoid/myeloid malignancy. Cumulative incidence rates and odds ratios were calculated. The crude 2-year incidence rate of lymphoid/myeloid malignancy among hospitalized CD patients was 3.87/1.000 CD patients (21/5,426; 95% CI = 2.40-5.92). The odds ratio adjusted for age, gender, and race was 2.04 (95% CI = 1.33-3.14, p < 0.001). The 2-year cumulative incidence of lymphoid/myeloid malignancies among hospitalized CD patients is greater than that seen in hospitalized patients without CD. This finding supports the need for further prospective population-based studies.
引用
收藏
页码:106 / 112
页数:7
相关论文
共 50 条
  • [1] Tabulation of myeloid, lymphoid and intestinal malignancies in Crohn's disease
    Freeman, HJ
    CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2002, 16 (11): : 779 - 784
  • [2] Incidence and impact of venous thromboembolism in hospitalized patients with Crohn's disease
    Keller, Karsten
    Sivanathan, Visvakanth
    Schmitt, Volker H.
    Ostad, Mir A.
    Muenzel, Thomas
    Espinola-Klein, Christine
    Hobohm, Lukas
    THROMBOSIS RESEARCH, 2022, 219 : 77 - 85
  • [3] Effect of CMV on Outcomes Among Hospitalized Patients With Crohn's Disease
    Kistangari, Gaurav
    Lopez, Rocio
    Shen, Bo
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2018, 113 : S359 - S359
  • [4] Incidence and impact of venous thromboembolism in hospitalized patients with Crohn-disease
    Keller, K.
    Sivanathan, V.
    Schmitt, V. H.
    Ostad, M. A.
    Munzel, T.
    Espinola-Klein, C.
    Hobohm, L.
    EUROPEAN HEART JOURNAL, 2022, 43 : 2641 - 2641
  • [5] Incidence of peri-pregnancy flares among patients with Crohn's disease
    Edward, Lee
    Robert, Suruki
    Robert, Fowler
    Gilwan, Kim
    Jeffrey, Stark
    Mohamed, Yassine
    Lisa, Pisenti
    Brenna, Brady
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2019, 114 : S26 - S26
  • [6] Combined Myeloid and Lymphoid Malignancies in 13 Elderly Patients
    Boxer, Michael
    Denes, Alex E.
    BLOOD, 2023, 142
  • [7] DISEASE FLARES AMONG PATIENTS WITH CROHN'S DISEASE
    Waters, H. C.
    Bolge, S. C.
    Freedman, D.
    Piech, C. T.
    VALUE IN HEALTH, 2009, 12 (03) : A131 - A131
  • [8] Second Myeloid and Lymphoid Malignancies in patients with Chronic Lymphocytic Leukemia
    Sandoval, Jose
    Corrales, Gabriela
    Rock-Klotz, Jennifer
    Pinilla-Ibarz, Javier
    Chavez, Julio
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2015, 15 : S207 - S207
  • [9] Incidence and Predictors of 30-day Readmission of Patients in Patients Hospitalized with Crohn's Disease: An Analysis of National Readmission Database
    Garg, Sushil
    Anugwom, Chimaobi M.
    Wadhwa, Vaibhav
    Shergill, Sukhman
    Gupta, Nancy
    Sanaka, Madhusudhan
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2016, 111 : S465 - S466
  • [10] Nutritional Screening and Clinical Outcome in Hospitalized Patients with Crohn's Disease
    Takaoka, Azusa
    Sasaki, Masaya
    Nakanishi, Naoko
    Kurihara, Mika
    Ohi, Akiko
    Bamba, Shigeki
    Andoh, Akira
    ANNALS OF NUTRITION AND METABOLISM, 2017, 71 (3-4) : 266 - 272