Neuroprotective effects of 2-heptyl-3-hydroxy-4-quinolone in HT22 mouse hippocampal neuronal cells

被引：5
|
作者：
Selvaraj, Baskar [1 ,5 ,6 ]
Kim, Dae Woon
Park, Jin-Soo [2 ,3 ]
Kwon, Hak Cheol [3 ]
Lee, Heesu [4 ]
Yoo, Ki-Yeon [4 ]
Lee, Jae Wook [1 ,5 ,6 ]
机构：
[1] Korea Inst Sci & Technol, Inst Nat Prod, Nat Prod Res Ctr, Gangnueng 25451, South Korea
[2] Gangneung Wonju Natl Univ, Coll Dent, Res Inst Oral Sci, Dept Biochem & Mol Biol, Kangnung, South Korea
[3] Korea Inst Sci & Technol, Inst Nat Prod, Nat Prod Informat Res Ctr, Gangnueng 25451, South Korea
[4] Gangneung Wonju Natl Univ, Inst Oral Sci, Coll Dent, Dept Oral Anat, Kangnung, South Korea
[5] Korea Inst Sci & Technol, Brain Sci Inst, Convergence Res Ctr Dementia, Gangnueng 02792, South Korea
[6] Univ Sci & Technol, Div Biomed Sci & Technol, Daejun 34113, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2021年 / 49卷
关键词：
Quinolone; Glutamate; Neuroprotective effects; HT22 hippocampal neuronal cells; MAPK; OXIDATIVE STRESS; GLUTAMATE; KINASE; DEATH; AIF; MITOCHONDRIA; INHIBITION; ACTIVATION; APOPTOSIS; TOXICITY;
D O I：
10.1016/j.bmcl.2021.128312
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The neuroprotective activity of 2-heptyl-3-hydroxy-4(1H)-quinolone (compound 1) was evaluated using the neurotoxicity of glutamate in the HT22 cell line. Compound 1, known as a signal molecule of the bacterial quorum-sensing system, protects neuronal cells from glutamate-induced neurotoxicity by inhibiting cellular Ca2+ uptake and glutamate-triggered ROS accumulation. MAPK signaling pathway inhibition by compound 1 was evaluated by immunoblotting the phosphorylation status of the proteins. Furthermore, pro-apoptotic protein levels and AIF translocation to the nucleus were found to be reduced by compound 1. In conclusion, compound 1 showed neuroprotective effects by inhibiting apoptotic neuronal cell death.
引用
收藏
页数：5
相关论文
共 50 条
  • [1] Neuroprotective effects of phenolic glycosides from Populus tomentiglandulosa roots in HT22 mouse hippocampal neuronal cells
    Kim, Soeun
    Lee, Phil Jun
    Fang, Bo
    Park, SeonJu
    Saravanakumar, Kandasamy
    Irfan, Navabshan
    Pham, Chau Ha
    Yoo, Guijae
    Yoo, Hee Min
    Cho, Namki
    JOURNAL OF MOLECULAR STRUCTURE, 2023, 1276
  • [2] Neuroprotective effects of Brazilian green propolis on oxytosis/ferroptosis in mouse hippocampal HT22 cells
    Takashima, Madoka
    Ichihara, Kenji
    Hirata, Yoko
    FOOD AND CHEMICAL TOXICOLOGY, 2019, 132
  • [3] Neuroprotective effects of Dendropanax morbifera leaves on glutamate-induced oxidative cell death in HT22 mouse hippocampal neuronal cells
    Park, Hye-Jin
    Kwak, Myounghai
    Baek, Seung-Hoon
    JOURNAL OF ETHNOPHARMACOLOGY, 2020, 251
  • [4] Effects of hypoxia on progranulin expression in HT22 mouse hippocampal cells
    Luo, Li
    Lu, Lanhai
    Lu, Yinghong
    Zhang, Lihong
    Li, Bofei
    Gu, Kaihua
    Chen, Lizhi
    Wang, Yang
    Shao, Yijia
    Xu, Jie
    MOLECULAR MEDICINE REPORTS, 2014, 9 (05) : 1675 - 1680
  • [5] Trypanosoma evansi interactome with mouse hippocampal neuronal cell (HT22)
    de Mello, Sandra Regina
    das Neves, Gabriella Bassi
    Marques, Julia
    Farina, Marcelo
    Alte, Glorister Alves
    Miletti, Luiz Claudio
    BIOPHYSICAL REVIEWS, 2021, 13 (06) : 1358 - 1358
  • [6] Neuroprotective effects of phenylenediarnine derivatives independent of an antioxidant pathway in neuronal HT22 cells
    Satoh, Takumi
    Izumi, Masanori
    NEUROSCIENCE LETTERS, 2007, 418 (01) : 102 - 105
  • [7] Neuroprotective Benzyl Benzoate Glycosides from Disporum viridescens Roots in HT22 Hippocampal Neuronal Cells
    Cho, Namki
    Yang, Heejung
    Lee, Mina
    Huh, Jungmoo
    Kim, Hyeon-Woo
    Kim, Hong-Pyo
    Sung, Sang-Hyun
    JOURNAL OF NATURAL PRODUCTS, 2013, 76 (12): : 2291 - 2297
  • [8] Constituents of Gastrodia elata and Their Neuroprotective Effects in HT22 Hippocampal Neuronal, R28 Retinal Cells, and BV2 Microglial Cells
    Kim, Hye Mi
    Kwon, Jaeyoung
    Lee, Kyerim
    Lee, Jae Wook
    Jang, Dae Sik
    Kwon, Hak Cheol
    PLANTS-BASEL, 2020, 9 (08): : 1 - 11
  • [9] Optimizing melatonin dosage for neuroprotection in HT22 hippocampal neuronal cells
    Mahdi, Abair
    Elamin, Abubaker Y.
    Hamour, Hala Mahgoub
    Abdelghani, Negwod
    Onger, Mehmet Emin
    Almasaad, Juman M.
    Alsharif, Mohammed H. Karrar
    Bakhit, Nagi M.
    Kaplan, Suleyman
    ANNALS OF PHYTOMEDICINE-AN INTERNATIONAL JOURNAL, 2024, 13 (01): : 836 - 842
  • [10] NEUROPROTECTIVE EFFECT OF SEED OF LOTUS PLUMULE IN THE MOUSE HIPPOCAMPAL HT22 CELL LINE
    Kim, Eun Sil
    Weon, Jin Bae
    Lee, Kyung Jin
    Ma, Choong Je
    PHARMACEUTICAL BIOLOGY, 2012, 50 (05) : 562 - 562
12345