Optimization of feed conditions in a 2.5-1 fed-batch culture using rice oil to improve cephalosporin C production by Cephalosporium acremonium M25

被引：6
|
作者：
Kim, NR [1 ]
Lim, JS [1 ]
Hong, SI [1 ]
Kim, SW [1 ]
机构：
[1] Korea Univ, Dept Biol & Chem Engn, Seoul 136701, South Korea
来源：
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY | 2005年 / 21卷 / 05期
基金：
欧洲研究理事会;
关键词：
cephalosporin C; Cephalosporium acremonium; fed-batch; feed conditions; rice oil;
D O I：
10.1007/s11274-004-3852-2
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Rice oil significantly affected cephalosporin C production in a 2.5-1 bioreactor culture of Cephalosporium acremonium M25. To improve cephalosporin C production, the feed conditions of rice oil were optimized. Reducing the feed rate of rice oil improved cephalosporin C production to 1.01 g/l when the consumption rate of rice oil decreased. Overall, under optimal feed conditions in the 2.5-1 fed-batch culture, cephalosporin C production increased about four times compared to before optimization.
引用
收藏
页码：787 / 789
页数：3
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