Total synthesis of clavosolide A via tandem allylic oxidation/oxa-conjugate addition reaction

被引：7

作者：

Baker, Joseph B. ^{[1
]}

Kim, Hyoungsu ^{[2
]}

Hong, Jiyong ^{[1
]}

机构：

[1] Duke Univ, Dept Chem, Durham, NC 27708 USA

[2] Ajou Univ, Coll Pharm, Suwon 443749, South Korea

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 23期

关键词：

Clavosolide; Total synthesis; Tandem reaction; Oxa-conjugate addition; gem-Disubstituent effect; Tetrahydropyran; NATURAL-PRODUCT (-)-CLAVOSOLIDE-A; STEREOSELECTIVE-SYNTHESIS; ABSOLUTE-CONFIGURATION; BENZOIC ANHYDRIDE; FORMAL SYNTHESIS; LACTONES; ESTERS;

D O I：

10.1016/j.tetlet.2014.11.135

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The tandem allylic oxidation/oxa-conjugate addition reaction promoted by the gem-disubstituent effect in conjunction with the NHC-mediated oxidative esterification was explored for the facile synthesis of clavosolide A. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：3120 / 3122

页数：3

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