A transfer-RNA-derived small RNA regulates ribosome biogenesis

被引：397

作者：

Kim, Hak Kyun ^{[1
,2
]}

Fuchs, Gabriele ^{[3
,6
,7
]}

Wang, Shengchun ^{[1
,2
,8
]}

Wei, Wei ^{[4
]}

Zhang, Yue ^{[1
,2
,9
]}

Park, Hyesuk ^{[1
,2
]}

Roy-Chaudhuri, Biswajoy ^{[1
,2
,10
]}

Li, Pan ^{[5
]}

Xu, Jianpeng ^{[1
,2
]}

Chu, Kirk ^{[1
,2
]}

Zhang, Feijie ^{[1
,2
]}

Chua, Mei-Sze ^{[4
]}

So, Samuel ^{[4
]}

Zhang, Qiangfeng Cliff ^{[5
]}

Sarnow, Peter ^{[3
]}

Kay, Mark A. ^{[1
,2
]}

机构：

[1] Stanford Univ, Dept Pediat, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Genet, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Microbiol & Immunol, Stanford, CA 94305 USA

[4] Stanford Univ, Dept Surg, Asian Liver Ctr, Sch Med, Stanford, CA 94305 USA

[5] Tsinghua Univ, Tsinghua Peking Joint Ctr Life Sci, Ctr Synthet & Syst Biol,MOE Key Lab Bioinformat, Beijing Adv Innovat Ctr Struct Biol,Sch Life Sci, Beijing 100084, Peoples R China

[6] SUNY Albany, RNA Inst, 1400 Washington Ave, Albany, NY 12222 USA

[7] SUNY Albany, Dept Biol Sci, 1400 Washington Ave, Albany, NY 12222 USA

[8] Medtron Vasc, 3576 Unocal Pl, Santa Rosa, CA 95403 USA

[9] Stanford Ctr Genom & Personalized Med, 3165 Porter Dr, Palo Alto, CA 94304 USA

[10] Impossible Foods Inc, 525 Chesapeake Dr, Redwood City, CA 94063 USA

来源：

NATURE | 2017年 / 552卷 / 7683期

基金：

美国国家卫生研究院;

关键词：

DIAMOND-BLACKFAN ANEMIA; CELL-PROLIFERATION; NUCLEIC-ACID; FRAGMENTS; REVEALS; GENE; EXPRESSION; PROTEINS; MATURATION; EFFICIENT;

D O I：

10.1038/nature25005

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Transfer-RNA-derived small RNAs (tsRNAs; also called tRNA-derived fragments) are an abundant class of small non-coding RNAs whose biological roles are not well understood. Here we show that inhibition of a specific tsRNA, LeuCAG3'tsRNA, induces apoptosis in rapidly dividing cells in vitro and in a patient-derived orthotopic hepatocellular carcinoma model in mice. This tsRNA binds at least two ribosomal protein mRNAs (RPS28 and RPS15) to enhance their translation. A decrease in translation of RPS28 mRNA blocks pre-18S ribosomal RNA processing, resulting in a reduction in the number of 40S ribosomal subunits. These data establish a post-transcriptional mechanism that can fine-tune gene expression during different physiological states and provide a potential new target for treating cancer.

引用

页码：57 / +

页数：21

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