Clinical application of the 70-gene profile: The MINDACT trial

被引：324

作者：

Cardoso, Fatima

Van't Veer, Laura

Rutgers, Emiel

Loi, Sherene

Mook, Stella

Piccart-Gebhart, Martine J.

机构：

[1] Inst Jules Bordet, B-1000 Brussels, Belgium

[2] Peter MacCallum Canc Ctr, Melbourne, Vic, Australia

[3] Netherlands Canc Inst, Amsterdam, Netherlands

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2008年 / 26卷 / 05期

关键词：

D O I：

10.1200/JCO.2007.14.3222

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The 70-gene profile is a new prognostic tool that has the potential to greatly improve risk assessment and treatment decision making for early breast cancer. Its prospective validation is currently ongoing through the MINDACT (Microarray in Node-Negative Disease May Avoid Chemotherapy) trial, a 6,000-patient randomized, multicentric trial. This article reviews the several steps in the development of the profile from its discovery to its clinical validation.

引用

页码：729 / 735

页数：7

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