The first total synthesis of a type II manumycin antibiotic, (+)-TMC-1A:: the total syntheses of (-)-LL-C10037β and (+)-manumycin B

被引：0

作者：

Grové, JJC ^{[1
]}

Wei, XD ^{[1
]}

Taylor, RJK ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

来源：

CHEMICAL COMMUNICATIONS | 1999年 / 05期

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A procedure using Na[PhSeB(OEt)(3)] is reported for conversion of the type I epoxy ketone manumycins into the type II beta-hydroxyketone variants; using this procedure, (-)-LL-C10037 beta and (+)-TMC-1A have been prepared for the first time; the first synthesis of(+)-manumycin B, which provides full stereochemical clarification of the natural product, is also described.

引用

页码：421 / 422

页数：2

共 12 条

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