Organogenesis in vitro

被引:11
|
作者
Iwasawa, Kentaro [1 ,2 ]
Takebe, Takanori [1 ,2 ,3 ,4 ,5 ]
机构
[1] Cincinnati Childrens Hosp Med Ctr, Div Gastroenterol Hepatol & Nutr, Cincinnati, OH 45229 USA
[2] Cincinnati Childrens Hosp Med Ctr, Div Dev Biol, Cincinnati, OH 45229 USA
[3] Cincinnati Childrens Hosp Med Ctr, Ctr Stem Cell & Organoid Med CuSTOM, Cincinnati, OH 45229 USA
[4] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45221 USA
[5] Tokyo Med & Dent Univ, Inst Res, Tokyo, Japan
关键词
ENDOTHELIAL-CELLS; HUMAN LIVER; MODEL; DIFFERENTIATION; INDUCTION; ORGANOIDS;
D O I
10.1016/j.ceb.2021.06.007
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Organoids are three-dimensional structures that self-organize from human pluripotent stem cells or primary tissue, potentially serving as a traceable and manipulatable platform to facilitate our understanding of organogenesis. Despite the ongoing advancement in generating organoids of diverse systems, biological applications of in vitro generated organoids remain as a major challenge in part due to a substantial lack of intricate complexity. The studies of development and regeneration enumerate the essential roles of highly diversified nonepithelial populations such as mesenchyme and endothelium in directing fate specification, morphogenesis, and maturation. Furthermore, organoids with physiological and homeostatic functions require direct and indirect inter-organ crosstalk recapitulating what is seen in organogenesis. We herein review the evolving organoid technology at the cell, tissue, organ, and system level with a main emphasis on endoderm derivatives.
引用
收藏
页码:84 / 91
页数:8
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