The authors present the clinical relevance of molecular genetics to laryngeal cancer in terms of helping to develop novel diagnostic, prognostic, and therapeutic strategies. They discuss how molecular diagnostics can detect abnormalities in lesions not yet appreciated histologically, and thus detect early recurrences. Patient management with novel targeted therapies for head and neck squamous cell carcinoma in the clinical arena is presented, with treatment options tailored to the individual patient and his or her cancer among them, with the goal of improving clinical outcomes.
机构:
Univ Michigan, Sch Med, Div Mol Med & Genet, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Ctr Canc, Dept Internal Med, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Ctr Canc, Dept Human Genet, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Ctr Canc, Dept Pathol, Ann Arbor, MI 48109 USAUniv Michigan, Sch Med, Div Mol Med & Genet, Ann Arbor, MI 48109 USA
Fearon, Eric R.
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 6,
2011,
6
: 479
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