Synthesis and structural characterization of three phenylsulfonyl derivatives: Influence of halogen substituents on the intermolecular interactions

Synthesis and X-ray structural determination of three halogenated nitroimidazo[1,2-a]pyridine phenylsulfonyl derivatives are reported. (2) is monoclinic P2(1)/c with a = 9.6679(1), b = 11.3642(2), c = 15.2189(2)angstrom, beta = 105.9053(7)degrees; (3) is triclinic P -1 with a = 8.5556(2), b = 13.1191(3), c = 15.5132(4)angstrom, alpha = 76.0110(8), beta = 89.1768(8), gamma = 78.953(2)degrees; (4) is monoclinic P2(1)/c with a = 15.3353(2), b = 8.8621(2), c = 11.4189(3)angstrom, beta = 90.9704(7)degrees. In the title compounds that differ by the nature and number of halogen substituents, the arylsulfonyl moieties are oriented differently relatively to the nitroimidazopyridine. Moreover non-classical intermolecular interactions are revealed by the X-ray analysis.