The synthesis of quinolines via denitrogenative palladium-catalyzed cascade reaction of o-aminocinnamonitriles with arylhydrazines

被引：11

作者：

Xie, Jing ^{[1
]}

Huang, Hang ^{[2
]}

Xu, Tong ^{[3
]}

Li, Renhao ^{[4
]}

Chen, Jiuxi ^{[3
]}

Ye, Xueting ^{[2
]}

机构：

[1] Wenzhou Med Univ, Affiliated Hosp 1, Dept Stomatol, Wenzhou 325000, Peoples R China

[2] Wenzhou Med Univ, Affiliated Hosp 1, Dept Urol, Wenzhou 325000, Peoples R China

[3] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325000, Peoples R China

[4] Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325000, Peoples R China

来源：

RSC ADVANCES | 2020年 / 10卷 / 15期

基金：

中国国家自然科学基金;

关键词：

TRANSITION-METAL-FREE; ARYL BORONIC ACIDS; TANDEM REACTION; ARYLATION; NITRILES; KETONES; CARBOPALLADATION; TRANSNITRILATION; HETEROCYCLES; ADDITIONS;

D O I：

10.1039/d0ra01043j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first example of the palladium-catalyzed cascade reaction of o-aminocinnamonitriles with arylhydrazines has been achieved, providing an efficient synthetic pathway to access quinolines with moderate to good yields. Preliminary mechanistic experiments indicate that this cascade process involves sequential denitrogenative addition followed by an intramolecular cyclization.

引用

页码：8586 / 8593

页数：8

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