Generalized Edema and Pseudothrombocytopenia After ChAdOx1 nCoV-19 COVID-19 Vaccination: A Case Report

被引:3
|
作者
Bokel, Joanna [1 ,2 ]
Mendes-de-Almeida, Daniela P. [1 ,3 ]
Martins-Goncalves, Remy [4 ]
Palhinha, Lohanna [4 ]
Vizzoni, Alexandre G. [1 ]
Correa, Danusa Ferreira [5 ]
Brandao, Luciana Gomes Pedro [5 ]
Bozza, Patricia T. [4 ]
Grinsztejn, Beatriz [6 ]
机构
[1] Fundacao Oswaldo Cruz FIOCRUZ, Dept Hematol, Inst Nacl Infectol Evandro Chagas, Rio De Janeiro, Brazil
[2] Onco Hematol Unit, Clin Sao Vicente, Rio De Janeiro, Brazil
[3] Inst Nacl Canc, Res Ctr, Rio De Janeiro, Brazil
[4] Fundacao Oswaldo Cruz FIOCRUZ, Lab Immunopharmacol, Inst Oswaldo Cruz, Rio De Janeiro, Brazil
[5] Fundacao Oswaldo Cruz FIOCRUZ, Hlth Surveillance & Immunizat Res Unit, Inst Nacl Infectol Evandro Chagas, Rio De Janeiro, Brazil
[6] Fundacao Oswaldo Cruz FIOCRUZ, Lab Clin Res STD AIDS, Inst Nacl Infectol Evandro Chagas, Rio De Janeiro, Brazil
关键词
generalized edema; pseudothrombocytopenia; spurious thrombocytopenia; COVID-19 vaccine safety; vaccine-induced pseudothrombocytopenia;
D O I
10.3389/fpubh.2022.907652
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Reports of side effects of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are increasing worldwide. Capillary leak syndrome and vaccine-induced immune thrombotic thrombocytopenia are very rare but life-threatening adverse events that should be identified early and treated. However, isolated thrombocytopenia can indicate pseudothrombocytopenia. In certain people, ethylenediaminetetraacetic acid (EDTA) induces an in vitro platelet aggregation, resulting in misleading underestimation of platelet counts. It is essential to recognize pseudothrombocytopenia to prevent diagnostic errors, overtreatment, anxiety, and unnecessary invasive procedures. We present a case who developed generalized edema and persistent pseudothrombocytopenia after the first dose of the ChAdOx1 nCoV-19 vaccine (AstraZeneca).
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页数:5
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