Accelerated binding of autoantibody to red blood cells with increasing anaemia in cattle experimentally infected with Theileria sergenti

被引：18

作者：

Shiono, H ^{[1
]}

Yagi, Y ^{[1
]}

Kumar, A ^{[1
]}

Yamanaka, M ^{[1
]}

Chikayama, Y ^{[1
]}

机构：

[1] Natl Agr & Biooriented Res Org, Natl Inst Anim Hlth, Hokkaido Res Stn, Sapporo, Hokkaido 0620045, Japan

来源：

JOURNAL OF VETERINARY MEDICINE SERIES B-INFECTIOUS DISEASES AND VETERINARY PUBLIC HEALTH | 2004年 / 51卷 / 01期

关键词：

D O I：

10.1111/j.1439-0450.2003.00724.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Anaemia is the most important clinical manifestation in cattle infected with Theileria sergenti. In order to determine the mechanism of red blood cells (RBC) destruction in anaemic cattle, we studied the binding of autoantibody (IgG) to RBC during the development of anaemia in T. sergenti infection. The low levels of IgG-bound RBC before the development of anaemia were triggered in proportion with the progression of anaemia and parasitaemia. Our results suggest an accelerated destruction of RBC in anaemic cattle by IgG-dependent phagocytosis.

引用

页码：39 / 42

页数：4

共 32 条

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