N-Heterocyclic Carbene Catalyzed Domino Reactions of Formylcyclopropane 1,1-Diesters: Construction of a 6-5-5 Tricyclic Pyrrolo[1,2-a]indole

被引：48
|
作者：
Li, Linxia [1 ]
Du, Ding [1 ]
Ren, Jun [1 ]
Wang, Zhongwen [1 ]
机构：
[1] Nankai Univ, State Key Lab Elementoorgan Chem, Inst Elementoorgan Chem, Tianjin 30071, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 2011卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Small ring systems; Carbenes; Domino reactions; Nitrogen heterocycles; Cycloaddition; ENANTIOSELECTIVE SYNTHESIS; CHIRAL CYCLOPROPANES; ALKYLATION REACTIONS; TANDEM REACTIONS; ALDEHYDES; DERIVATIVES; CHEMISTRY; REACTIVITY; THIAZOLIUM; INHIBITOR;
D O I：
10.1002/ejoc.201001364
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Catalyzed by N-heterocyclic carbenes (NHCs), a domino ring-opening/redox amidation/Knoevenagel condensation of readily available formylcyclopropane 1,1-diesters with 1H-indole-2-carbaldehydes is reported. This methodology provides a new and direct method for the construction of a 6-55 tricyclic pyrrolo[1,2-a] indole skeleton.
引用
收藏
页码：614 / 618
页数：5
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