Prognostic Landscape of Tumor-Infiltrating T and B Cells in Human Cancer

被引:10
|
作者
Zheng, Ming [1 ,2 ]
Li, Yi-Ming [3 ,4 ,5 ]
Liu, Zhen-Yu [3 ,4 ,5 ]
Zhang, Xin [6 ]
Zhou, Yinghui [3 ,4 ,5 ,6 ]
Jiang, Jian-Li [3 ,4 ,5 ]
Zhu, Ping [5 ,6 ]
Yang, Xiang-Min [3 ,4 ,5 ]
Tang, Juan [3 ,4 ,5 ]
Chen, Zhi-Nan [3 ,4 ,5 ]
机构
[1] Acad Mil Med Sci, Inst Mil Cognit & Brain Sci, Beijing, Peoples R China
[2] Beijing Inst Basic Med Sci, Beijing, Peoples R China
[3] Fourth Mil Med Univ, Cell Engn Res Ctr, State Key Lab Canc Biol, Xian, Peoples R China
[4] Fourth Mil Med Univ, Dept Cell Biol, Xian, Peoples R China
[5] Natl Translat Sci Ctr Mol Med, Xian, Peoples R China
[6] Fourth Mil Med Univ, Xijing Hosp, Dept Clin Immunol, Xian, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2022年 / 12卷
基金
中国国家自然科学基金;
关键词
tumor-infiltrating lymphocytes; tumor-infiltrating B cells; tumor-infiltrating T cells; cancer; prognosis; single-cell RNA-sequencing; tumor microenvironment; IMMUNE CELLS; LYMPHOCYTES; PHENOTYPE; RELEVANCE; SURVIVAL; GENES;
D O I
10.3389/fimmu.2021.731329
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Recently, immunotherapy targeting tumor-infiltrating lymphocytes (TILs) has emerged as a critical and promising treatment in several types of cancer. However, not all cancer types have been tested in immunotherapeutic trials, and different patients and cancer types may have unpredictable clinical outcomes. This situation has created a particular exigency for analyzing the prognostic significance of tumor-infiltrating T cells (TIL-T) and B cells (TIL-B) across different cancer types. To address the critical role of TILs, the abundances of TIL-T and TIL-B cells, as determined by the protein levels of LCK and CD20, were analyzed across heterogeneous human malignancies. TIL-T and TIL-B cells showed varying prognostic significances across heterogeneous cancer types. Additionally, distinct distributions of TIL-T and TIL-B cells were observed in different cancer and tumor microenvironment (TME) subtypes. Next, we analyzed the cellular context for the TME communication network involving the well-acknowledgeable chemokine receptors of TIL-T and TIL-B cells, implying the functional interactions with TME. Additionally, these chemokine receptors, expressed by TIL-T and TIL-B cells, were remarkably correlated with the levels of TIL-T or TIL-B cell infiltrations across nearly all the cancer types, indicating these chemokine receptors as universal targets for up- and down-regulating the TIL-T and TIL-B cells. Lastly, we provide the prognostic landscape of TIL-T and TIL-B cells across 30 cancer types and the subgroups defined by gender, histopathology, histological grade, therapeutic approach, drug, and TME subtype, which are intended to be a resource to fuel the investigations of TILs, with important implications for cancer immunotherapy.
引用
收藏
页数:14
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