Synthesis and Antitubercular Activity of Some Novel N′-Substituted Benzenesulfonamide Derivatives

2-Oxo-N-(4-(N-substituted phenylsulfamoyl)phenyl)propanamides 2(a-e)/4-oxo-N-(4-(N-substituted phenylsul famovl)phenyl)pentanam ides 4(a-c) were prepared by refluxing 4-am ino-N-substituted phenylbenzenesulfonamides 1(a-e)/1(a-c) with pyruvic acid/levulinic acid in the presence of thionyl chloride for about 1 h. The synthesis of N-(4-(N(4-bromophenyl) sulfamoyl) phenyl)-2-(2-(4-1H-pyrrol-1-yl) benzoyl) hydrazineylidene) propanamide 3a/4-(2-(4-(1H-pyrrol-1yl) benzoyl) hydrazineylidene)-N-(4-(N-substituted phenylsulfamoyl) phenyl) pentanamides 5(a-b) was achieved by refluxing compound 2a/4(a-b) with 4-(1H-pyrrol-1-yl) benzohydrazide in alcohol in the presence of acetic acid. All the newly synthesized compounds were screened for in vitro antitubercular activity against Mycobacterium tuberculosis H37R.v and exhibited significant minimum inhibitory concentration values. [GRAPHICS] .