In this paper, an overview of chemical analysis capabilities that support Pu-238 programs for space applications and the progress of establishing these capabilities at the Los Alamos Plutonium Facility will be discussed. These chemical and in-line analysis capabilities include (1) UV-visible spectrometry for Pu Assay, (2) nuclear detection systems (integrated gamma-ray and alpha spectrometry, and gas proportional counter) for radiochemical analysis, (3) direct-current are (DC Are) and inductively coupled plasma mass spectrometry (ICP-MS) for trace analysis, (4) plutonium process monitoring (PPM) system for ion-exchange operations, and (5) solution in-line alpha counter (SILAC) for gross alpha determination of aqueous solutions.