Crypt cell kinetics in denervated small intestine following antrectomy

Previous studies have shown that antrectomy (which decreases gastrin production) is associated with decreased crypt cell proliferation rate throughout the gastrointestinal tract. However, the present experiments demonstrate that there is hyperproliferation of the crypts throughout the rat small bowel following antrectomy, and this hyperproliferation can be completely negated by bilateral truncal vagotomy or local sympathectomy of the small bowel. These results support the probable involvement of the autonomic nerve supply in the control of crypt cell proliferation (for which there is also other evidence). They also confirm the findings of other researchers that gastrin is not involved in the control of crypt cell proliferation in the small bowel to any extent. Med Sci Res 26:555-556 (C) 1998 Lippincott Williams & Wilkins.