Three-Component Visible-Light-Induced Palladium-Catalyzed 1,2-Alkyl Carbamoylation/Cyanation of Alkenes

被引：38
|
作者：
Jia, Xiangqing [1 ]
Zhang, Ziyan [1 ]
Gevorgyan, Vladimir [1 ]
机构：
[1] Univ Texas Dallas, Dept Chem & Biochem, Richardson, TX 75080 USA
来源：
ACS CATALYSIS | 2021年 / 11卷 / 21期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
difunctionalization; isocyanide; radical; palladium; light-induced; C-H ALKYLATION; CARBENE; DICARBOFUNCTIONALIZATION; ISOCYANIDES; TERTIARY; OLEFINS;
D O I：
10.1021/acscatal.1c04183
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A mild visible-light-induced Pd-catalyzed one-pot three-component alkyl-carbamoylation and cyanation of alkenes was developed. This general transformation, which proceeds via the in situ formation of a reactive ketenimine intermediate, allows for a rapid construction of a broad range of valuable amides and nitriles from readily available alkenes, alkyl iodides, and isocyanides. An efficient synthesis of tetrazole and amidine via this approach was also demonstrated.
引用
收藏
页码：13217 / 13222
页数：6
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