A Conformationally Frozen Peptoid Boosts CXCR4 Affinity and Anti-HIV Activity

被引：47
|
作者：
Demmer, Oliver [1 ,2 ]
Frank, Andreas O. [1 ,2 ]
Hagn, Franz [1 ,2 ]
Schottelius, Margret [3 ]
Marinelli, Luciana [4 ]
Cosconati, Sandro [5 ]
Brack-Werner, Ruth [6 ]
Kremb, Stephan [6 ]
Wester, Hans-Juergen [3 ]
Kessler, Horst [1 ,2 ]
机构：
[1] Tech Univ Munich, Inst Adv Study, Dept Chem, D-85748 Garching, Germany
[2] King Abdulaziz Univ, Dept Chem, Fac Sci, Jeddah 21589, Saudi Arabia
[3] Lehrstuhl Pharmazeut Radiochem, Garching, Germany
[4] Univ Naples Federico II, Dipartimento Chim Farmaceut & Tossicol, Naples, Italy
[5] Univ Naples 2, Dipartimento Sci Ambientali, Caserta, Italy
[6] Helmholtz Zentrum Munchen, Inst Virol Neuherberg, Neuherberg, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 32期
关键词：
biological activity; drug design; medicinal chemistry; peptides; peptidomimetics; CHEMOKINE RECEPTOR CXCR4; PEPTIDES; AMD3100; ANTAGONISTS; DISCOVERY; INFECTION; LIGAND; CELLS; LESTR/FUSIN; INHIBITORS;
D O I：
10.1002/anie.201202090
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
引用
收藏
页码：8110 / 8113
页数：4
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