Strategies for Distinguishing Low-grade Endometrioid and Serous Carcinomas of Endometrium

被引：36

作者：

Garg, Karuna ^{[1
]}

Soslow, Robert A. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10065 USA

来源：

ADVANCES IN ANATOMIC PATHOLOGY | 2012年 / 19卷 / 01期

关键词：

endometrium; serous carcinomas; endometrioid carcinomas; morphologically ambiguous carcinomas; COMPLEX ATYPICAL HYPERPLASIA; P53 PROTEIN OVEREXPRESSION; BETA-CATENIN; MICROSATELLITE INSTABILITY; PROGNOSTIC-SIGNIFICANCE; IMMUNOHISTOCHEMICAL EXPRESSION; CLINICOPATHOLOGICAL ANALYSIS; MOLECULAR ALTERATIONS; FAVORABLE-PROGNOSIS; PAPILLARY CARCINOMA;

D O I：

10.1097/PAP.0b013e318234ab36

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Distinction between endometrioid and serous carcinomas of the endometrium has important prognostic and therapeutic implications. Misdiagnosing a serous carcinoma as endometrioid can have significant consequences for the patient and pathologist. Although many cases are straightforward and easy to classify, there are occasional problematic cases. This review focuses on strategies that help differentiate between low-grade endometrioid carcinoma and serous carcinoma of the endometrium. We will discuss clinical, morphologic, and immunohistochemical differences between the 2 entities and provide practical tips for practicing pathologists when confronted with this differential diagnosis.

引用

页码：1 / 10

页数：10

共 50 条

[1] Cytokeratin 19 Expression in Normal Endometrium and in Low-grade Endometrioid Adenocarcinoma of the Endometrium
Stewart, Colin J. R.
Crook, Maxine L.
Lacey, Joanne
Louwen, Kathryn
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2011, 30 (05) : 484 - 491
[2] Markers of proliferative activity are predictors of patient outcome for low-grade endometrioid adenocarcinoma but not papillary serous carcinoma of endometrium
Al Kushi, A
Lim, P
Aquino-Parsons, C
Gilks, CB
MODERN PATHOLOGY, 2002, 15 (04) : 365 - 371
[3] The continuum of serous tumors of low malignant potential and low-grade serous carcinomas of the ovary
Wong, Kwong-Kwok
Gershenson, David
DISEASE MARKERS, 2007, 23 (5-6) : 377 - 387
[4] Intratumoral heterogeneity in a minority of ovarian low-grade serous carcinomas
Tone, Alicia A.
McConechy, Melissa K.
Yang, Winnie
Ding, Jiarui
Yip, Stephen
Kong, Esther
Wong, Kwong-Kwok
Gershenson, David M.
Mackay, Helen
Shah, Sohrab
Gilks, Blake
Tinker, Anna V.
Clarke, Blaise
McAlpine, Jessica N.
Huntsman, David
BMC CANCER, 2014, 14
[5] Intratumoral heterogeneity in a minority of ovarian low-grade serous carcinomas
Alicia A Tone
Melissa K McConechy
Winnie Yang
Jiarui Ding
Stephen Yip
Esther Kong
Kwong-Kwok Wong
David M Gershenson
Helen Mackay
Sohrab Shah
Blake Gilks
Anna V Tinker
Blaise Clarke
Jessica N McAlpine
David Huntsman
BMC Cancer, 14
[6] Molecular Characterization of Undifferentiated Carcinomas That Are Associated with Low-Grade Endometrioid Carcinoma
Kuhn, E.
Bahadirli-Talbott, A.
Ayhan, A.
Debeljak, M.
Eshleman, J.
Zhao, C.
Shih, I-M
MODERN PATHOLOGY, 2013, 26 : 283A - 283A
[7] Molecular Characterization of Undifferentiated Carcinomas That Are Associated with Low-Grade Endometrioid Carcinoma
Kuhn, E.
Bahadirli-Talbott, A.
Ayhan, A.
Debeljak, M.
Eshleman, J.
Zhao, C.
Shih, I-M
LABORATORY INVESTIGATION, 2013, 93 : 283A - 283A
[8] Molecular targeting of low-grade serous and mucinous carcinomas of the ovary or peritoneum
Gershenson, David M.
TRANSLATIONAL CANCER RESEARCH, 2015, 4 (01) : 29 - 39
[9] Uterine serous and Grade 3 endometrioid carcinomas - Is there a survival difference?
Boruta, DM
Gehrig, PA
Groben, PA
Bae-Jump, V
Boggess, JF
Fowler, WC
Van Le, L
CANCER, 2004, 101 (10) : 2214 - 2221
[10] Testing for NRAS Mutations in Serous Borderline Ovarian Tumors and Low-Grade Serous Ovarian Carcinomas
Sadlecki, Pawel
Grzanka, Dariusz
Grabiec, Marek
DISEASE MARKERS, 2018, 2018

← 1 2 3 4 5 →