Syntheses and properties of trimethylaminophenoxy-substituted Zn(II)-phthalocyanines

被引：19

作者：

Ongarora, Benson G. ^{[1
]}

Hu, Xiaoke ^{[1
]}

Li, Hairong ^{[1
]}

Fronczek, Frank R. ^{[1
]}

Vicente, M. Graca H. ^{[1
]}

机构：

[1] Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA

来源：

MEDCHEMCOMM | 2012年 / 3卷 / 02期

基金：

美国国家卫生研究院;

关键词：

PHOTODYNAMIC THERAPY; CATIONIC PORPHYRINS; PHOTOCHEMICAL PROPERTIES; PHTHALOCYANINES; MITOCHONDRIA; LOCALIZATION; COMPLEXES; DEATH; CELLS;

D O I：

10.1039/c1md00232e

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The syntheses, photophysical properties and in vitro biological behavior of a series of nine Zn(II)-phthalocyanines (ZnPcs) bearing one to eight positively-charged trimethylaminophenoxy groups are reported. All ZnPcs are highly soluble in polar organic solvents, and show fluorescence and singlet oxygen quantum yields in the ranges 0.11-0.21 and 0.16-0.47, respectively. The cytotoxicity of the ZnPcs depends on both the number of charges and their site of substitution (alpha vs. beta) on the Pc isoindole units; the most promising for PDT application are the alpha-substituted di-cationic ZnPcs 6a and 17a.

引用

页码：179 / 194

页数：16

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