Cholesterol and obesity: A marker for Alzheimer's disease

Modern lifestyle and fast-food consumption nature increase the cholesterol consumption and deposition in our body. It is becoming one of the key risk factors in AD development. Several genes and receptors play crucial roles in such developments. Consumption of high-fat diet and absence of physical activity can lead to obesity. Higher BMI is the indicator of obesity. Higher BMI accelerates AD development due to brain atrophy, neuroinflammation, and oxidative stress in the hippocampus. Obesity in childhood and adolescence leads to dementia and AD in later life. COVID harmfully affects Alzheimer's patients, and it is also reported that COVID related dementia and neurodegeneration is one of the prominent post-COVID complications. This review summarises the role of cholesterol in Alzheimer's disease development and the importance of genes, receptors, and diet behind this.