Neural correlates of interindividual differences in the subjective experience of pain

被引:400
作者
Coghill, RC [1 ]
McHaffie, JG
Yen, YF
机构
[1] Wake Forest Univ, Sch Med, Dept Anat & Neurobiol, Winston Salem, NC 27157 USA
[2] Wake Forest Univ, Sch Med, Ctr Study Pharmacol Plast Presence Pain, Winston Salem, NC 27157 USA
[3] Univ Western Ontario, Dept Diagnost Radiol & Nucl Med, London, ON N6A 4G5, Canada
关键词
D O I
10.1073/pnas.1430684100
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Some individuals claim that they are very sensitive to pain, whereas others say that they tolerate pain well. Yet, it is difficult to determine whether such subjective reports reflect true interindividual experiential differences. Using psychophysical ratings to define pain sensitivity and functional magnetic resonance imaging to assess brain activity, we found that highly sensitive individuals exhibited more frequent and more robust pain-induced activation of the primary somatosensory cortex, anterior cingulate cortex, and prefrontal cortex than did insensitive individuals. By identifying objective neural correlates of subjective differences, these findings validate the utility of introspection and subjective reporting as a means of communicating a first-person experience.
引用
收藏
页码:8538 / 8542
页数:5
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