Automated foveal location detection on spectral-domain optical coherence tomography in geographic atrophy patients

Purpose To develop a fully automated algorithm for accurate detection of fovea location in atrophic age-related macular degeneration (AMD), based on spectral-domain optical coherence tomography (SD-OCT) scans. Methods Image processing was conducted on a cohort of patients affected by geographic atrophy (GA). SD-OCT images (cube volume) from 55 eyes (51 patients) were extracted and processed with a layer segmentation algorithm to segment Ganglion Cell Layer (GCL) and Inner Plexiform Layer (IPL). Their en face thickness projection was convolved with a 2D Gaussian filter to find the global maximum, which corresponded to the detected fovea. The detection accuracy was evaluated by computing the distance between manual annotation and predicted location. Results The mean total location error was 0.101 +/- 0.145mm; the mean error in horizontal and vertical en face axes was 0.064 +/- 0.140mm and 0.063 +/- 0.060mm, respectively. The mean error for foveal and extrafoveal retinal pigment epithelium and outer retinal atrophy (RORA) was 0.096 +/- 0.070mm and 0.107 +/- 0.212mm, respectively. Our method obtained a significantly smaller error than the fovea localization algorithm inbuilt in the OCT device (0.313+0.283mm, p <.001) or a method based on the thinnest central retinal thickness (0.843 +/- 1.221, p <.001). Significant outliers are depicted with the reliability score of the method. Conclusion Despite retinal anatomical alterations related to GA, the presented algorithm was able to detect the foveal location on SD-OCT cubes with high reliability. Such an algorithm could be useful for studying structural-functional correlations in atrophic AMD and could have further applications in different retinal pathologies.